Callus: A Symptom Of Throat Cancer? Find Out More Here!

 At any point each one of us has developed calluses and corns. However, some of calluses and corns are serious and uncomfortable like extreme thickening of the skin is one of the symptoms of having a particular type of esophageal cancer. According to the recent study found there is a relation between having a foot calluses and esophageal cancer with the animals and human as well.

Medical News Today defined callus or callosity as a part of skin that became thicker than the usual texture due to the friction or the pressure given. However, blisters and calluses are two different things; blisters are results of excessive rubbing which can be harmful while calluses are not that serious as blister except there are some calluses that can lead to infection or ulceration of the skin. While cancer is a type of disease that was described where there is an out-of-control cell growth.

Research made by the Queen Mary University of London in the United Kingdom, study the relation between keratin (protein in the outer layer of the skin that plays an important key role in the formation of calluses) and a type of esophageal cancer called "tylosis." In the United Kingdom, tylosis made a great effect with people whereas it caused severe thickening of the skin with their hands and feet in conclusion medical experts refer to this condition as tylosis with esophageal cancer (TOC).

However, recent research led by authors Thiviyani Maruthappu and Anissa Cheikh published in Nature Communications found that there's this particular gene called iRHOM2 that plays a crucial role in thickening of the skin, found to control keratin formation and linker to TOC. The researchers tried to remove the iRHOM2 gene with a group of mice and found out that these mice developed a much thinner layer of skin compared with mice that still contain the iRHOM2 gene.

In line with this, with iRHOM2-free mice they found that there is a lesser expression of keratin 16 (K16). Researchers do the same examination and observation with the K16 levels in human with TOC and found that there is just a similar result.As a result, iRHOM2 gene can control the formation of keratin in both humans and mice.

Be cautious and watch the video about the symptoms and treatment for TOC: